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Care should be taken when administering Dutamax to patients taking potent, chronic CYP3A4 inhibitors. doku lucky pinjol Dutamax does not inhibit the in vitro metabolism of model substrates for the major human cytochrome P450 isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) at a concentration of 1,000 ng/ml, 25 times greater than steady-state serum concentrations in humans. doku lucky pinjol